protective effects of the morus alball. leaves extracts on cisplatin-induced nephrotoxicity in rat

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Protective effects of the Morus alba L. leaf extracts on cisplatin-induced nephrotoxicity in rat

Cisplatin (CP) as an important anti-tumor drug causes nephrotoxicity mainly by oxidative stress and renin-angiotensin system (RAS). Since flavonoids have high antioxidant activity and probable role in the inhibition of RAS, this study was designed to investigate the protective effect of hydroalcoholic extract and flavonoid fraction of Morus alba leaves on cisplatin-induced nephrotoxicity in rat...

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protective effects of the morus alba l. leaf extracts on cisplatin-induced nephrotoxicity in rat

cisplatin (cp) as an important anti-tumor drug causes nephrotoxicity mainly by oxidative stress and renin-angiotensin system (ras). since flavonoids have high antioxidant activity and probable role in the inhibition of ras, this study was designed to investigate the protective effect of hydroalcoholic extract and flavonoid fraction of morus alba leaves on cisplatin-induced nephrotoxicity in rat...

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Protective Effect of Aqueous and Ethanolic Extracts of Portulaca Oleracea Against Cisplatin Induced Nephrotoxicity

Objective(s) Portulaca oleracea L. is a herbaceous weed from portulacaceae family. It can be found in many parts of the world. Modern pharmacological studies have demonstrated that P. oleracea have antioxidant effects. The protective effect of aqueous and ethanolic extract of P. oleracea against cisplatin-induced renal toxicity was studied in rats. Materials and Methods Single intraperitonea...

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Protective effects of ethyl pyruvate in cisplatin-induced nephrotoxicity

This study was performed to investigate the effect of ethyl pyruvate on changes in renal functions and oxidative stress related renal injury caused by cisplatin (cis-dichlorodiammine platinum-II; CDDP). Male Wistar albino rats were divided into four groups (n = 8): (1) control group (1 ml Ringer's lactate solution i.p.); (2) ethyl pyruvate (EP) group (50 mg/kg Ringer's EP solution (REPS) i.p.);...

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Protective Effects of Berberine on Bromobenzene-Induced Nephrotoxicity in Mice

Introduction: Bromobenzene is an environmental toxin whose metabolites cause renal toxicity. The mechanism involved in toxicity includes oxidative stress. The aim of this study was to investigate the protective effects of berberine against bromobenzene-induced renal toxicity in male NMRI mice. Materials and Methods: In this experimental study, subjects were divided into five groups. Group I...

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Protective Effect of Safranal against Gentamicin-Induced Nephrotoxicity in Rat

Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....

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research in pharmaceutical sciences

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